As recently as six years ago, three human diseases with similar phenotypes were mistakenly believed to be caused by a single genetic defect. The three diseases, Ataxia-telangiectasia, Nijmegen breakage syndrome, and an AT-like disorder are now known, however, to have defects in three separate genes: ATM, NBS1, and MRE11. Furthermore, new recent studies have shown now that all three gene products interact; the ATM kinase phosphorylates NBS1,1 which, in turn, associates with MRE11 to regulate DNA repair. Remarkably or expectedly, depending (...) on one's point of view, the similarity in disease phenotypes is evidently due to defects in a common DNA repair pathway. BioEssays 22:966–969, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

Voigt's 1887 explanation of the Michelson-Morley result as a Doppler effect using absolute space-time is examined. It is shown that Doppler effects involve two wave velocities: (1) the phase velocity, which is used to account for the Michelson-Morley null result, and (2) the velocity of energy propagation, which, being fixed relative to absolute space, may be used to explain the results of Roemer, Bradley, Sagnac, Marinov, and the 2.7° K anisotropy.

It is suggested that the existence of a preferred cosmological reference frame has a number of generally unrecognized implications which are by no means inconsistent with the assumptions and consequences of special relativity. Indeed, the assumption that there exists a cosmological fundamental reference frame for light propagation leads to an intelligible interpretation of relativistic effects and of the null observations of Michelson-Morley-type experiments. Hence all such experiments are impotent for the detection of any such fundamental frame, and it is (...) shown that this applies also to the ingenious coupled-mirrors experiment proposed by S. Marinov. Only astronomical observation allied to cosmological theory can reveal the existence of this frame. (shrink)

We propose a new picture of nature in which there are only two fundamental universal constantsè ē (≡e/c) andh(≡ħ/c). Our theory is developed within the framework of a new four-dimensional symmetry which is constructed on the basis of the Poincaré-Einstein principle of relativity for the laws of physics and the Newtonian concept of time. We obtain a new space-light transformation law, a velocity-addition law, and so on. In this symmetry scheme, the speed of light is constant and is completely relative. (...) The new theory is logically self-consistent, and it moreover is in agreement with all previously established experimental facts, such as the “lifetime dilatation” of unstable particles, the Michelson-Morley experiment, etc. There is a difference relative to the usual theory, though, in that our theory predicts a new law for the Dopplerfrequency shift, which can be tested experimentally by measuring the second-order frequency shift. (shrink)

The Michelson-Morley result is described empirically by generalized Doppler equations. If the phase of a light wave is not invariant, in agreement with the quantum nature of light, special-relativistic kinematics need not be assumed. Einstein particle dynamics and Maxwell-Lorentz electrodynamics in a moving system are derived without assuming special-relativistic kinematics. An alternative explanation for the decay rate of moving radioactive particles is presented. The observation of a third-order Doppler effect may yield the velocity of the closed laboratory.

After reviewing the foundations of special relativity and the room left for rival theories, a set of nonrelativistic para-Lorentzian transformations is derived uniquely, based on (a) a weaker first principle, (b) the requirement that the transformations sought do not give rise to the clock “paradox” (in a refined version), and (c) the compliance of the transformations with the classical experiments of Michelson-Morley, Kennedy-Thorndike, and Ives-Stilwell. The corresponding dynamics is developed. Most of the experimental support of special relativity is reconsidered (...) in the light of the new theory. It is concluded that the relativity of simultaneity has so far not been tested. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:John Dewey: The ChicagoYears GEORGE DYKHUIZEN DEWEYCAMETO CHICAGOin the summer of 1894 as head professor of philosophy at the University of Chicago and left in January, 1905, to become professor of philosophy at Columbia University. During his Chicago years, Dewey's interests led him not only into the field of philosophy but also into that of education, and in each of these areas he acquired a retmtation which placed him (...) among the top thinkers in the country. His work in philosophy resulted in his being acclaimed, along with Charles S. Peirce and William James, as one of the three great founders of American pragmatism, and his achievements in education led to his being regarded as one of the country's most outstanding educational thinkers and a prime mover in educational reform. The University of Chicago was only four years old when Dewey arrived there, but already it had attained a high standing among the universities of the country. The main reason for this was that the University had set out to be not simply another college but a university, like the universities in Europe and like Johns Hopkins and Clark universities in this country. This meant that the graduate schools of the University were to be stressed and that a large part of the faculty was to devote itself exclusively to graduate instruction and research. The type of faculty member the University looked for "must be a teacher, but first and foremost he must be a scholar, in love with learning, with a passion for research, an investigator who could produce, and if what he produced was worthy, would wish to publish." ~ In the four years since its founding, the University had assembled one of the most outstanding faculties in the country, a faculty which included: T. C. Chamberlin in astronomy, Rolin D. Salisburg in geology, Albert Michelson in physics, Jacques Loeb in biology, J. M. Coulter in botany, Thorsten Veblen in political economy, Albion Small in sociology, Paul Shorey in Greek, J. H. Breasted in Egyptology, and R. G. Moulton in English. When Dewey came to the University, therefore, as head of the Department of Philosophy, this meant that he was to teach mostly graduate students, do research, and have associations with some of the most brilliant scholars in the country. These features of the new position had appealed strongly to Dewey when he was considering the offer to 1T. W. Goodspeed, A History of the University of Chicago. The First Quarter (Chicago: 1916), 201. [227] 228 HISTORY OF PHILOSOPHY become professor of philosophy at Chicago and were among the decisive factors in bringing him to the University. William Rainey Harper, president of the University, was in large measure responsible for its early successes. "Those massive buildings, millions of money, thousands of scholars and scores of teachers," wrote one of his admirers, "are a monument to the foresight, nerve, and ceaseless activity of W. R. Harper, a veritable Napoleon in the educational field." 2 Born July 26, 1856, Harper was three years older than Dewey and every bit as precocious. He received his A.B. degree from Muskingum College when he was fourteen; he entered Yale as a graduate student when he was seventeen and got his Ph.D. degree from there at the age of nineteen. Upon receiving his doctorate, he began a career teaching Hebrew first at the Baptist Union Theological Seminary in Chicago and then, in 1886, at Yale. Harper wrote extensively on theological matters and his views prompted an attack on his orthodoxy in 1888. He weathered the storm, however, and throughout his life was a staunch defender of liberal theological thought. Harper had tremendous vitality and enthusiasm, and these qualities, along with his scholarship, led to his appointment as first president of the University when it was founded in 1890. Harper and Dewey were to have close associations on the administrative level, and though many of these were to be pleasant and cordial, others turned out to be not so harmonious and led eventually to Dewey's resignation from the University. Though Harper was particularly concerned that a strong department of philosophy be established at the University, up to the time of Dewey's... (shrink)

Summary: Responding to Laudan’s skeptical reading of history an influential group of realists claim that the seriously wrong claims past successful theories licensed were not really implicated in the predictions that once singled them out as successful. For example, in the case of Fresnel’s theory of light, it is said that although he appealed to the ether he didn’t actually need to in order to derive his famous experimental predictions—in them, we are assured, the ether concept was “idle,” “inessential,” “peripheral” (...) or worse. This view, developed by J. Worrall and P. Kitcher in the 1980s and subsequently supplemented by J. Leplin and by S. Psillos has received critical attention in the literature over the last decade, but more needs to be said on the subject—or so I suggest in this paper. I bring forward four converging argumentative lines to show how and why, from the days of Fresnel to at least the decade after the Michelson-Morley experiments, the ether functioned and was understood as an “essential” posit in physics. My first line draws Fresnel’s actual deployment of the ether concept and the way he and his circle understood the achievements of his theory. The second line draws is from epistemological assessments of surprising implication in theories and its impact on leading theorists in the last two-thirds of the century. The third line draws from discussions of the optical ether in end-of-century reports circa 1900. The fourth focuses on entrenched metaphysical assumptions that persisted in the practice of physics until the advent of special relativity. Pulling these four lines together shows, I think, why attempts at synchronic identification of sound theory-parts are bound to fail, and also how realists might try to meet the challenge this creates. (shrink)

Summary: Responding to Laudan’s skeptical reading of history an influential group of realists claim that the seriously wrong claims past successful theories licensed were not really implicated in the predictions that once singled them out as successful. For example, in the case of Fresnel’s theory of light, it is said that although he appealed to the ether he didn’t actually need to in order to derive his famous experimental predictions—in them, we are assured, the ether concept was “idle,” “inessential,” “peripheral” (...) or worse. This view, developed by J. Worrall and P. Kitcher in the 1980s and subsequently supplemented by J. Leplin and by S. Psillos has received critical attention in the literature over the last decade, but more needs to be said on the subject—or so I suggest in this paper. I bring forward four converging argumentative lines to show how and why, from the days of Fresnel to at least the decade after the Michelson-Morley experiments, the ether functioned and was understood as an “essential” posit in physics. My first line draws Fresnel’s actual deployment of the ether concept and the way he and his circle understood the achievements of his theory. The second line draws is from epistemological assessments of surprising implication in theories and its impact on leading theorists in the last two-thirds of the century. The third line draws from discussions of the optical ether in end-of-century reports circa 1900. The fourth focuses on entrenched metaphysical assumptions that persisted in the practice of physics until the advent of special relativity. Pulling these four lines together shows, I think, why attempts at synchronic identification of sound theory-parts are bound to fail, and also how realists might try to meet the challenge this creates. (shrink)

Of all the developments in twentieth century physics, none has given rise to more heated debates than the changes in our understanding of science precipitated by the quantum revolution''. In this revolution, Niels Bohr's dramatically non-classical theory of the atom proved to be the springboard from which the new atomic physics drew it's momentum. Furthermore, Bohr's contribution was crucial not only because his interpretation of quantum mechanics became the most widely accepted view but also because in his role as educator (...) and spokesman for atomic physics Bohr was very much the patron spirit of the entire quantum revolution. The conceptual framework which he proposed to provide a new viewpoint for understanding the quantum theoretical description of atomic systems became for most of this century the dominant outlook of countless productive experimental and theoretical physicists. He called this new framework complementarity''. (shrink)

Trope theory is a leading metaphysical theory in analytic ontology. One of its classic statements is found in the work of Donald C. Williams who argued that tropes qua abstract particulars are the very alphabet of being. The concept of an abstract particular has been repeatedly attacked in the literature. Opponents and proponents of trope theory alike have levelled their criticisms at the abstractness of tropes and the associated act of abstraction. In this paper I defend the concept of a (...) trope qua abstract particular by rejecting arguments that purport to show that tropes should not be understood as abstract and by arguing that the abstractness of tropes plays an indispensable role in one of our more promising trope-theoretic analyses of universals and of concrete objects. (shrink)

In Working Virtue: Virtue Ethics and Contemporary Moral Problems, leading figures in the fields of virtue ethics and ethics come together to present the first ...

Discusses the experiments of Aristotle, William Beaumont, Robert Norman, Stephen Hales, Konrad Lorenz, Galileo, Robert Boyle, Theodoric of Freibourg, Louis Pasteur, Ernest Rutherford, A.A. Michelson, E.W. Morley, F. Jacob, E. Wollman, J.J. Gibson, A.L. Lavoisier, Humphrey Davy, J.J. Thomson, Isaac Newton, Michael Faraday, J.J. Berzelius, and Otto Stern.

The concept of instantiation is realized differently across a variety of metaphysical theories. A certain realization of the concept in a given theory depends on what roles are specified and associated with the concept and its corresponding term as well as what entities are suited to fill those roles. In this paper, the classic realization of the concept of instantiation in a one-category ontology of abstract particulars or tropes is articulated in a novel way and defended against unaddressed objections.

Fifteen essays addressing conceptions of individualism and holism as they emerged in Chinese literature and philosophy from the time of Confucius and Chuang-tzu to the present.

Human languages vary in many ways but also show striking cross-linguistic universals. Why do these universals exist? Recent theoretical results demonstrate that Bayesian learners transmitting language to each other through iterated learning will converge on a distribution of languages that depends only on their prior biases about language and the quantity of data transmitted at each point; the structure of the world being communicated about plays no role (Griffiths & Kalish, , ). We revisit these findings and show that when (...) certain assumptions about the relationship between language and the world are abandoned, learners will converge to languages that depend on the structure of the world as well as their prior biases. These theoretical results are supported with a series of experiments showing that when human learners acquire language through iterated learning, the ultimate structure of those languages is shaped by the structure of the meanings to be communicated. (shrink)

In management research, theory testing confronts a paradox described by Meehl in which designing studies with greater methodological rigor puts theories at less risk of falsification. This paradox exists because most management theories make predictions that are merely directional, such as stating that two variables will be positively or negatively related. As methodological rigor increases, the probability that an estimated effect will differ from zero likewise increases, and the likelihood of finding support for a directional prediction boils down to a (...) coin toss. This paradox can be resolved by developing theories with greater precision, such that their propositions predict something more meaningful than deviations from zero. This article evaluates the precision of theories in management research, offers guidelines for making theories more precise, and discusses ways to overcome barriers to the pursuit of theoretical precision. (shrink)

Rooted in the field of cathedral studies, this paper draws into dialogue three bodies of knowledge: Edward Bailey’s notion of implicit religion that, among other things, highlights the continuing traction of the Christian tradition and Christian practice within secular societies; David Walker’s notion of the multiple ways through which in secular societies people may relate to the Christian tradition as embodied within the Anglican Church and John Fisher’s notion of spiritual wellbeing as conceptualised in relational terms. Against this conceptual background, (...) this paper draws on data provided by 1234 participants attending one of the Christmas Eve carol services in Liverpool Cathedral to explore the perceived impact of attendance on the spiritual health of people who do not believe in God and yet feel that Liverpool Cathedral is their cathedral, and it is this sense of belonging that brings them back at Christmas time.Contribution: Situated within the science of cathedral studies, this paper links in an original way three fields of discourse: Edward Bailey’s notion of implicit religion, David Walker’s notion of the four ways of belonging to God facilitated by the Anglican Church and John Fisher’s conceptualisation and operationalisation of the notion of spiritual wellbeing. The hypothesis developed from this original integration of theoretical perspectives is then tested empirically on data provided by 404 participants at carol services who do not believe in God. (shrink)

Semantic Scholar extracted view of "Animal Welfare and Rights: V. Zoos and Zoological Parks" by J. Dunlap et al.

In Animal Rites, Cary Wolfe examines contemporary notions of humanism and ethics by reconstructing a little known but crucial underground tradition of theorizing the animal from Wittgenstein, Cavell, and Lyotard to Lévinas, Derrida, ...

This article has two objectives. First, and in particular, it seeks to reinterpret the ostracism procedure of early democratic Athens. Since Aristotle, this has been understood as a rational, political weapon of collective defense, intended to expel from Athens a disproportionately powerful individual. In this article, by putting emphasis on themateriality, gestures, and location of ostraka-casting, I propose instead that the institution can more fruitfully be understood as a ritual enactment of civic unity. Second, and more generally, I hope to (...) explore the frames within which early Athenian democracy is placed: while Greek kingship and tyranny (i.e. “primitive” polities) have been very successfully explored through anthropological and cross-cultural comparison, Greek democracy for the most part has remained in the domains of the institutional historian and political theorist. Taking a phenomenological and comparative approach, this article asks how the citizens of early democratic Athens experienced and comprehended their new sovereignty and the invented procedures of mass decision-making through which it was expressed. (shrink)

I INTRODUCTION: RESPECT, EQUALITY AND THE AUTONOMY OF MORALITY We often invoke a notion of respect to express our sense of human equality. ...

The mechanistic theory of life.--Criticism of the mechanistic theory.--Biology and the physical sciences.--Personality.

This book is unified by three broad concerns: the rationality of belief in God, the relation between religion and morality, and the explication of the concept of God. The essays are, however, marked by diversity. Some focus on historical figures, such as Aquinas and Locke; others bring recent epistemological and metaphysical developments to bear on problems of religious belief. Some of the papers explore neglected issues central to religious practice, such as the question of how total devotion to God can (...) permit other deep commitments; others apply philosophical distinctions from within a religious tradition, for example, in setting out a Christian approach to the problem of evil. (shrink)

This is a fresh and vitally important step past stymied debate on what is arguably the most pressing issue in cross-disciplinary feminist theory.

Two conceptual strands of research within the field of cathedral studies have theorised the capacity of Anglican cathedrals to engage more successfully than parish churches with the wider non-churchgoing community. One strand has explored mobilising cathedral metaphors, and the other strand has explored the notion of implicit religion. Both strands illuminate the power of events and installations to soften the boundaries between common ground and sacred space. Drawing on a quantitative survey among 978 people who attended the pre-Christmas son et (...) lumiere at Liverpool Cathedral during December 2022, the present study analyses the qualitative responses of 123 participants who never attend church services. Three categories of themes emerged from these data, concerning the Cathedral itself, the installation, and discordant experience.Contribution: Situated within the science of cathedral studies, this article draws on original qualitative data to illuminate the experiences of participants who never attend church services when engaging with the pre-Christmas son et lumiere at a major cathedral. Conceptualised within the framework of implicit religion, these data confirmed how the son et lumiere succeeded in softening boundaries between the sacred and the secular and provided a deeply moving experience. As one participant said, ‘I am not religious, but I had the best experience ever’. (shrink)

The continuing power of racist ideology threatens liberal democracy, for racism is more than a personal bias or a social construction. It is an ideological framework that reduces human beings to an existence along a color-coded spectrum, with people designated as “white” at the top of the hierarchy and people designated as “black” at the bottom. One has to see this ideology clearly in order to choose a proper response and then act accordingly. First, the reality of “race” has been (...) exposed as unscientific and illusory, and as based not on biology or genetics, but on a legacy of empowerment for some and enslavement for others. Second, this racist ideology, part of our disenchanted, secular age, is exposed as a continuing form of enchantment in its manner of seeing the world, opening the possibility for a spiritual response. Third, dismantling this racist ideology requires a reimagining of “blackness” as a source of life and spirituality, as a way of countering and rewriting the dominant racist narrative. Fourth, a postsecular spiritualty, based on the work of Pope Francis—that emphasizes the importance of protecting our common human dignity, of caring for each other, and of “walking together”—can be engaged as a path for action in the battle against racism. (shrink)

Normative realists tend to consider evolutionary debunking arguments as posing epistemological challenges to their view. By understanding Sharon Street’s ‘Darwinian dilemma’ argument in this way, they have overlooked and left unanswered her unique scientific challenge to normative realism. This paper counters Street’s scientific challenge and shows that normative realism is compatible with an evolutionary view of human evaluative judgment. After presenting several problems that her adaptive link account of evaluative judgments faces, I outline and defend an evolutionary byproduct perspective on (...) evaluative judgment. I then argue that a consideration of levels of analysis in biological–behavioral explanation suggests that the realist who adopts the byproduct perspective I outline is not at a prima facie disadvantage to the normative anti-realist on grounds of parsimony. This perspective, I suggest, can enable normative realists to answer evolutionary challenges to their view. (shrink)

The problem of stability in population dynamics concerns many domains of application in demography, biology, mechanics and mathematics. The problem is highly generic and independent of the population considered (human, animals, molecules,…). We give in this paper some examples of population dynamics concerning nucleic acids interacting through direct nucleic binding with small or cyclic RNAs acting on mRNAs or tRNAs as translation factors or through protein complexes expressed by genes and linked to DNA as transcription factors. The networks made of (...) these interactions between nucleic acids (considered respectively as edges and nodes of their interaction graph) are complex, but exhibit simple emergent asymptotic behaviours, when time tends to infinity, called attractors. We show that the quantity called attractor entropy plays a crucial role in the study of the stability and robustness of such genetic networks. (shrink)

Anti-realism is plagued by Fitch’s paradox: the remarkable result that if one accepts that all truths are knowable, minimal assumptions about the nature of knowledge entail that every truth is known. Dorothy Edgington suggests to address this problem by understanding p is knowable to be a counterfactual claim, but her proposal must contend with a forceful objection by Timothy Williamson. I revisit Edgington’s basic idea and find that Williamson’s objection is obviated by a refined understanding of counterfactual knowability that is (...) grounded in possible courses of inquiry. I arrive at a precise definition of knowability that is not just a technical avoidance of paradox, but is metaphysically sound and does justice to the anti-realist idea. (shrink)

Prize offered for most innovative web publication A t present, the Journal of Medical Ethics appears in duplicate: one version on the web, one version in paper. There has been little difference between these two copies. But the web and paper publishing offer different opportunities for the reader. A bound conventional paper copy of a journal offers a compact, transportable, easily readable, discrete collection of knowledge. It ….